Weighted clustering of called array CGH data
نویسندگان
چکیده
منابع مشابه
Weighted clustering of called array CGH data
Array comparative genomic hybridization (aCGH) is a laboratory technique to measure chromosomal copy number changes. A clear biological interpretation of the measurements is obtained by mapping these onto an ordinal scale with categories loss/normal/gain of a copy. The pattern of gains and losses harbors a level of tumor specificity. Here, we present WECCA (weighted clustering of called aCGH da...
متن کاملWeighted clustering of called array CGH data.
Array comparative genomic hybridization (aCGH) is a laboratory technique to measure chromosomal copy number changes. A clear biological interpretation of the measurements is obtained by mapping these onto an ordinal scale with categories loss/normal/gain of a copy. The pattern of gains and losses harbors a level of tumor specificity. Here, we present WECCA (weighted clustering of called aCGH da...
متن کاملModel-based clustering of array CGH data
MOTIVATION Analysis of array comparative genomic hybridization (aCGH) data for recurrent DNA copy number alterations from a cohort of patients can yield distinct sets of molecular signatures or profiles. This can be due to the presence of heterogeneous cancer subtypes within a supposedly homogeneous population. RESULTS We propose a novel statistical method for automatically detecting such sub...
متن کاملEvaluating array-CGH based clustering of tumors
DNA preparation to cancer profiles •Many of the changes in the genome associated to cancer can be seen by making gene copy number measurements. Increased copy numbers of genes are associated with oncogenes and decreased copy numbers are associated with tumor suppressor genes. •Array-based Comparative Genomic Hybridization (arrayCGH), introduced in the late nineties, allows efficient characteriz...
متن کاملCGH-Explorer: a program for analysis of array-CGH data
SUMMARY CGH-Explorer is a program for visualization and statistical analysis of microarray-based comparative genomic hybridization (array-CGH) data. The program has preprocessing facilities, tools for graphical exploration of individual arrays or groups of arrays, and tools for statistical identification of regions of amplification and deletion.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biostatistics
سال: 2007
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxm048